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Sp1 transcription factor : ウィキペディア英語版 | Sp1 transcription factor
Transcription factor Sp1, also known as specificity protein 1 * is a protein that in humans is encoded by the SP1 gene. == Function ==
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor.〔 In the SV40 virus, Sp1 binds to the GC boxes in the regulatory region (RR) of the genome.
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